Key result
Antihypertensive therapy in adults ≥60 cuts all-cause mortality ~9% and lowers cardiovascular events vs control.
Why the study?
Hypertension increases with age, most rapidly over age 60, making it important to determine the benefits and harms of antihypertensive treatment in this population, including subgroups aged 60 to 79 and 80 years or older.
Does antihypertensive drug treatment reduce all-cause mortality and cardiovascular morbidity in healthy adults 60 years or older with hypertension?
Systematic Review (n=26,795)
Does antihypertensive drug treatment reduce all-cause mortality and cardiovascular morbidity in healthy adults 60 years or older with hypertension?
Effect estimate: RR 0.91 (95% CI 0.85 to 0.97)
Absolute Event Rate: 10% vs 11%
Antihypertensive therapy, primarily with first-line thiazide diuretics, significantly reduces all-cause mortality and cardiovascular events in healthy adults aged 60 years and older with moderate to severe hypertension.
Supports antihypertensive therapy in healthy adults ≥60; confirms mortality and CV benefit in this population.
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Musini et al. (2025) conducted a systematic review in Moderate to severe systolic and/or diastolic hypertension (n=26,795). Antihypertensive drug treatment vs. Placebo or no treatment was evaluated on All-cause mortality (RR 0.91, 95% CI 0.85 to 0.97). Antihypertensive drug therapy in adults ≥60 years old reduced all-cause mortality (10% vs 11%; RR 0.91; 95% CI 0.85-0.97) and cardiovascular morbidity and mortality compared with control.
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