Key result
HCM shows modest arrhythmic progression over four years marked by increased PVCs and AF.
Why the study?
Although 48-hour Holter monitoring is recommended to identify NSVT in HCM, the cumulative 48-hour risk of NSVT and arrhythmic disease progression during follow-up remained to be estimated.
What is the rate of arrhythmic disease progression over a 4-year follow-up period in patients with hypertrophic cardiomyopathy?
Cohort
What is the rate of arrhythmic disease progression over a 4-year follow-up period in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, there is a modest progression of arrhythmic disease over 4 years, characterized by increased premature ventricular contractions and atrial fibrillation.
May inform arrhythmia monitoring in HCM; hypothesis-generating for progression rates in observational data.
Background: Forty-eight-hour Holter-monitoring (HM) is recommended to identify nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). This study aims to estimate the cumulative 48-hour risk of NSVT in HCM and assess arrhythmic disease progression during follow-up evaluation. Methods: HCM patients were retrospectively identified from 2017 to 2020 and were evaluated from patient records. Patients with a minimum of 2 available HM periods were included. Conclusions: This study demonstrated a modest arrhythmic disease progression in HCM patients during a 4-year follow-up period, with a significant increase in premature ventricular contractions and atrial fibrillation, and a trend toward an increase in NSVT.
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Bjerregaard et al. (2025) conducted a cohort in Hypertrophic cardiomyopathy. 48-hour Holter-monitoring was evaluated on Cumulative 48-hour risk of NSVT and arrhythmic disease progression (p== 0.01). During a 4-year follow-up, hypertrophic cardiomyopathy patients demonstrated modest arrhythmic disease progression with a significant increase in premature ventricular contractions and atrial fibrillation (P=0.01).
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