May 21, 2026Journal of the American College of Cardiology
Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy
Key result
Holter-detected NSVT yields a ~95% negative predictive value for sudden death in HCM.
- n=178
Why the study?
Ventricular tachyarrhythmias on Holter ECG are known markers for sudden death in highly selected HCM populations, but their profile and significance in a nontertiary-based cohort remained to be determined.
Does the presence of nonsustained ventricular tachycardia on ambulatory Holter ECG predict sudden death in patients with hypertrophic cardiomyopathy?
Population
178 patients with HCM in a nontertiary-based cohort
Comparison
Arrhythmia profiles on ambulatory 24-h Holter ECG
Design
Cohort study
Follow-up
5.5 +/- 3.4 years
Authors
Discussion
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Implication
Holter-detected arrhythmias may aid risk stratification in HCM; leaves open whether targeted intervention improves survival.
Key Points
- Investigate the types and prognostic significance of arrhythmias detected by Holter ECG in patients with hypertrophic cardiomyopathy.
- Conducted ambulatory Holter electrocardiogram monitoring on a cohort of hypertrophic cardiomyopathy patients.
- Analyzed the spectrum of arrhythmias and their correlation with patient outcomes.
- Certain arrhythmias were significantly associated with worse outcomes (exact rates not specified).
- The presence of specific arrhythmias correlated with increased mortality risk.
Study Design
Type
Cohort (n=178)
Structured PICO
Does the presence of nonsustained ventricular tachycardia on ambulatory Holter ECG predict sudden death in patients with hypertrophic cardiomyopathy?
P
Population
178 patients with hypertrophic cardiomyopathy from a nontertiary-based cohort, followed for a mean of 5.5 years.
E
Exposure
Ambulatory 24-h Holter ECG monitoring
O
Outcome
Clinical outcome (sudden death) and profile of ventricular and supraventricular ectopy and bradyarrhythmiahard clinical
In a nontertiary HCM cohort, NSVT on Holter ECG is common but has a low positive predictive value (9%) and high negative predictive value (95%) for sudden death.
Cite This Study
Adabağ et al. (2005) conducted a cohort in Hypertrophic cardiomyopathy (n=178). Nonsustained ventricular tachycardia on ambulatory 24-h Holter ECG vs. Absence of nonsustained ventricular tachycardia was evaluated on Sudden death. Nonsustained ventricular tachycardia on Holter ECG had a 9% positive predictive value and 95% negative predictive value for sudden death in a nontertiary hypertrophic cardiomyopathy cohort.