Population
In vitro biochemical model involving villin and actin filaments
Design
Preclinical
Authors
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Distinct Ca2+ thresholds enable selective villin capping in vitro; leaves open in vivo relevance and any cardiovascular translation.
The concentration of ionized calcium required for villin's capping activity is about 4 orders of magnitude lower than that required for its cutting activity, allowing complete separation of the two functions.
Northrop et al. (1986) studied this question.
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