Population
Polymerized actin labeled with a fluorescent probe on either lysine-374 or cysteine-375
Comparison
High calcium concentrations in the presence of… vs Low calcium concentrations with villin, and…
Design
Preclinical
Authors
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Villin's calcium-regulated actin cutting versus capping extends cytoskeletal mechanism insights; leaves open any cellular or clinical relevance.
This basic science study demonstrates that villin's ability to cut versus cap actin filaments is regulated by different calcium binding sites with distinct affinities.
Walsh et al. (1984) studied this question.