Key result
24-hour ambulatory BP variability is not linked to CAC in borderline high BP.
Why the study?
Does 24-hour ambulatory blood pressure variability associate with coronary artery calcium in low-risk individuals with borderline high blood pressure?
Observational (n=322)
Does 24-hour ambulatory blood pressure variability associate with coronary artery calcium in low-risk individuals with borderline high blood pressure?
In a low cardiovascular risk population with borderline high blood pressure, 24-hour ambulatory blood pressure variability is not associated with the presence of coronary artery calcium.
Answers are grounded in this paper and cite their sources.
No association in this low-risk cohort does not support BP variability for CAC stratification; leaves open its role in higher-risk groups.
Blood pressure (BP) variability is associated with progression to clinical atherosclerosis. The evidence is inconclusive if BP variability predicts cardiovascular outcomes in low-risk populations. The aim of this study was to analyze the association of 24-hour BP variability with coronary artery calcium (CAC) among a group of individuals without coronary artery disease. The Masked Hypertension Study targeted patients with borderline high BP (120-149 mm Hg systolic and/or 80-95 mm Hg diastolic). Ambulatory blood pressure monitoring (ABPM) was performed at two time-points, 8 days apart. CAC was measured at exit visit via cardiac CT and reported as Agatston Score. Weighted standard deviations and average real variability were calculated from ABPM. Of the 322 participants who underwent cardiac CT, 26% (84) had CAC present, 52% (168) were female, and 21% (64) were black. BP variability did not differ by CAC group. In this low cardiovascular risk group, CAC was not associated with 24-hour ambulatory BP variability.
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DeBarmore et al. (2018) conducted an observational in Borderline high blood pressure without coronary artery disease (n=322). 24-hour ambulatory blood pressure variability was evaluated on Coronary artery calcium (CAC). 24-hour ambulatory blood pressure variability was not associated with the presence of coronary artery calcium in a cohort of 322 participants with borderline high BP (26% had CAC present).
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