What question did this study set out to answer?

To update survival estimates and identify independent prognostic factors influencing clinical outcomes among patients diagnosed with colorectal cancer in Ghana.

December 29, 2025BMC GastroenterologyOpen Access

Prognostic factors and survival outcomes in colorectal cancer: insights from a Ghanaian cohort

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Authors

TBTonnies Abeku BuckmanMadurai Medical College SSSamuel Asamoah SakyiKwame Nkrumah University of Science and Technology JYJoseph Yorke

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Implication

Retrospective cohort study reveals low five-year survival and key prognostic risks in colorectal cancer patients, highlighting the urgent need for early detection.

Key Points

To update survival estimates and identify independent prognostic factors influencing clinical outcomes among patients diagnosed with colorectal cancer in Ghana.
Retrospective analysis of N=281 colorectal cancer patients diagnosed between 2016 and 2022 at Komfo Anokye Teaching Hospital in Kumasi, Ghana.
Overall survival was evaluated using the Kaplan-Meier method and log-rank tests, with multivariable Cox proportional hazards models applied to identify independent prognostic factors.
The 5-year overall survival rate was 39.3% (95% CI: 28.7–49.9) with a median overall survival of 45 months (95% CI: 32.5–57.5), and late-stage presentation was predominant (Stage III: 39.1%, Stage IV: 29.9%).
Decreased overall survival was independently associated with stage II disease (aHR = 13.50, 95% CI: 1.74–104.75), stage IV disease (aHR = 10.41, 95% CI: 1.16–93.11), multiple comorbidities (aHR = 2.72, 95% CI: 1.15–6.46), smoking (aHR = 1.72, 95% CI: 1.06–2.81), and herbal medicine use (aHR = 1.58, 95% CI: 1.04–2.38).
Employment in the informal sector was independently associated with improved overall survival (aHR = 0.57, 95% CI: 0.36–0.89).

Cite This Study

Buckman et al. (2025) studied this question.

synapsesocial.com/papers/6a08944e113ba5b476de4bb9 https://doi.org/10.1186/s12876-025-04405-w

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Implication

Retrospective cohort study reveals low five-year survival and key prognostic risks in colorectal cancer patients, highlighting the urgent need for early detection.

Prognostic factors and survival outcomes in colorectal cancer: insights from a Ghanaian cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Prognostic factors and survival outcomes in colorectal cancer: insights from a Ghanaian cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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