Key result
Preliminary data from multiple trials presented at ACC 2006 highlighted findings on darbepoetin alfa, rosuvastatin, carvedilol, ultrafiltration, and CMR imaging in cardiovascular disease.
This update summarizes preliminary data from ACC 2006 on various cardiovascular interventions, including heart failure treatments, lipid-lowering therapy, and imaging.
Should not change practice based on 2006 preliminary signals; leaves open need for confirmatory trial publications.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the American College of Cardiology 55th Annual Scientific Session held in March 2006. All reports should be considered as preliminary data, as analyses may change in the final publication. Darbepoetin alfa increased haemoglobin levels in heart failure patients and improved some aspects of quality of life compared to placebo. In the ASTEROID study rosuvastatin significantly reduced LDL-cholesterol levels and induced regression of atherosclerosis in patients with CAD. Rosuvastatin also produced a significant reduction in LDL-cholesterol levels in heart failure patients in the UNIVERSE study, but had no effect on left ventricular remodelling compared to placebo. The paediatric carvedilol study failed to show a benefit of carvedilol in children with heart failure. Ultrafiltration produced a greater weight and fluid loss than intravenous diuretics in heart failure patients with volume overload in the UNLOAD study but did not exert a greater improvement in breathlessness; however, ultrafiltration did reduce readmission rates. The ICELAND MI study showed that CMR imaging was more sensitive than ECG or clinical criteria for detecting myocardial infarction.
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Cleland et al. (2006) conducted a review in Heart failure, coronary artery disease, myocardial infarction. Multiple interventions (darbepoetin alfa, rosuvastatin, carvedilol, ultrafiltration, CMR) vs. Placebo, intravenous diuretics, ECG/clinical criteria was evaluated. Preliminary data from multiple trials presented at ACC 2006 highlighted findings on darbepoetin alfa, rosuvastatin, carvedilol, ultrafiltration, and CMR imaging in cardiovascular disease.
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