Key result
Cardiomyocyte grafts achieve myocardial remuscularization but clinical translation requires highly predictive animal models.
Highlights the importance of selecting appropriate animal models to successfully translate myocardial remuscularization therapies to clinical trials.
Model selection may determine remuscularization translation success; leaves open which animal models best predict clinical outcomes.
Myocardial re-muscularization can be achieved by implantation of cardiomyocyte-containing grafts. Critical steps towards clinical translation of the 1(st) generation cardiac re-muscularization therapies include the choice of animal models with high predictive validity for therapeutic outcome in clinical trials.
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Wolfram‐Hubertus Zimmermann (2017) studied this question. Cardiomyocyte-containing grafts can achieve myocardial remuscularization, but successful clinical translation requires selecting animal models with high predictive validity.
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