February 1, 1996Cell TransplantationOpen Access

Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: Long-term survival and phenotypic modification of implanted myoblasts

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Why the study?

Can arterially delivered skeletal myoblasts engraft and undergo phenotypic modification in the murine heart?

Population

Murine heart model

Design

Preclinical

Follow-up

4 months

Authors

SRSarita RobinsonUniversity of Lancashire

Discussion

Member takes

Implication

Hypothesis-generating for arterial myoblast delivery in cardiac repair; leaves open translation to larger models or humans.

Structured PICO

Can arterially delivered skeletal myoblasts engraft and undergo phenotypic modification in the murine heart?

Population

Murine heart model

Intervention

Genetically labeled C2C12 skeletal myoblasts introduced into the arterial circulation via transventricular injection

Outcome

Engraftment, long-term survival, and phenotypic modification of implanted myoblastssurrogate

Arterial delivery of skeletal myoblasts allows for successful engraftment and phenotypic adaptation in the murine heart, suggesting potential for myocardial regeneration therapies.

Cite This Study

Sarita Robinson (1996) studied this question.

synapsesocial.com/papers/6a7e374f3eabdb005bb299b7 https://doi.org/10.1016/0963-6897(95)02016-0

View Full Paper

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Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: Long-term survival and phenotypic modification of implanted myoblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: Long-term survival and phenotypic modification of implanted myoblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider