Key result
Cardiac mast cell density was significantly higher in patients with idiopathic dilated and ischemic cardiomyopathy (18.4 cells/mm2) compared to controls (5.3 cells/mm2; P<.01).
Why the study?
Does cardiac mast cell density and mediator release differ in patients with idiopathic and ischemic cardiomyopathy compared to controls?
Observational (n=44)
Does cardiac mast cell density and mediator release differ in patients with idiopathic and ischemic cardiomyopathy compared to controls?
Absolute Event Rate: 18.4% vs 5.3%
p-value: p=<.01
Mast cell density and mediator release are significantly increased in failing hearts from patients with DCM and ICM, suggesting a potential role in cardiac fibrosis and remodeling.
No takes yet. Share an insight, caveat, or question.
May implicate mast cells in remodeling; leaves open whether targeting them alters progression in DCM or ICM.
Patella et al. (1998) conducted an observational in Idiopathic dilated and ischemic cardiomyopathy (n=44). Idiopathic dilated and ischemic cardiomyopathy vs. Control subjects without cardiovascular disease was evaluated on Cardiac mast cell (HHMC) density (p=<.01). Cardiac mast cell density was significantly higher in patients with idiopathic dilated and ischemic cardiomyopathy (18.4 cells/mm2) compared to controls (5.3 cells/mm2; P<.01).
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