Key result
Disodium cromoglycate significantly reduced myocardial fibrosis and prevented infiltration and degranulation of mast cells in rats with postmyocarditis dilated cardiomyopathy.
Why the study?
Does disodium cromoglycate reduce myocardial fibrosis in a rat model of postmyocarditis dilated cardiomyopathy?
Does disodium cromoglycate reduce myocardial fibrosis in a rat model of postmyocarditis dilated cardiomyopathy?
p-value: p=<0.01
Mast cell stabilization with disodium cromoglycate reduces myocardial fibrosis and mast cell infiltration in a rat model of postmyocarditis dilated cardiomyopathy, suggesting mast cells play a key role in its pathogenesis.
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Supports mast cell stabilization in fibrosis models; leaves open translation to human postmyocarditis dilated cardiomyopathy.
Selvaraj et al. (2005) studied Postmyocarditis Dilated Cardiomyopathy (n=40). Disodium cromoglycate (DSCG) vs. Saline (vehicle) was evaluated on Myocardial fibrosis area (p=<0.01). Disodium cromoglycate significantly reduced myocardial fibrosis and prevented infiltration and degranulation of mast cells in rats with postmyocarditis dilated cardiomyopathy.