Key result
HF links to increased renal sympathetic nerve activity and norepinephrine spillover driven by altered reflexes.
This review summarizes the mechanisms of renal sympatho-excitation in heart failure, focusing on afferent reflexes and central mechanisms.
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May inform sympatho-modulatory strategies in HF; leaves open prospective validation of afferent-central targets.
Ramchandra et al. (2015) conducted a review in Heart failure. Heart failure is associated with an increase in renal sympathetic nerve activity and norepinephrine spillover, driven by alterations in afferent reflexes and central mechanisms.
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