Effect of obesity and being overweight on long-term mortality in congestive heart failure: influence of left ventricular systolic function
Why the study?
Does body mass index influence long-term mortality in hospitalized congestive heart failure patients, and is this effect modified by left ventricular systolic function?
Population
4,700 hospitalized congestive heart failure patients with available body mass index data. Left ventricular…
Comparison
Abnormal body mass index vs Normal weight
Design
Cohort
Follow-up
5 to 8 years
Authors
Discussion
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Member takes
Implication
Caution advised interpreting obesity as protective in systolic HF; extends obesity paradox literature by LVEF modification.
Structured PICO
Does body mass index influence long-term mortality in hospitalized congestive heart failure patients, and is this effect modified by left ventricular systolic function?
P
Population
4,700 hospitalized congestive heart failure (CHF) patients with available body mass index (BMI) data. Left ventricular systolic function assessment was available for 95% of patients.
I
Intervention
Abnormal body mass index (underweight, overweight, or obese)
C
Comparator
Normal weight
O
Outcome
Long-term mortalityhard clinical
The 'obesity paradox' in heart failure is complex and modified by left ventricular systolic function, with obesity actually conferring an increased mortality risk in patients with systolic dysfunction.
Cite This Study
Gustafsson et al. (2004) studied this question.