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January 1, 2012Cardiology Research and PracticeOpen Access

Left Atrial Appendage Exclusion for Stroke Prevention in Atrial Fibrillation

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Key result

Mechanical exclusion of the left atrial appendage offers an alternative strategy for stroke prevention in patients with atrial fibrillation who are deemed unsuitable for oral anticoagulation.

Population

Patients with atrial fibrillation, particularly those deemed unsuitable for oral anticoagulation

Design

Review

Authors

TPTaral K. PatelATP Clinical Research (United States)
Clyde W. Yancy
Clyde W. YancyHeart Failure / Cardiomyopathy
Bradley P. Knight
Bradley P. KnightElectrophysiology

Discussion

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Overview

May support LAA exclusion in anticoagulation-ineligible AF; leaves open need for randomized outcome trials.

Structured PICO

P
Population
Patients with atrial fibrillation, particularly those deemed unsuitable for oral anticoagulation
I
Intervention
Mechanical exclusion, removal, or occlusion of the left atrial appendage (LAA)
O
Outcome
Stroke prevention

This review highlights recent advances and available devices for mechanical exclusion of the left atrial appendage as an alternative strategy for stroke prevention in patients with atrial fibrillation.

Cite This Study

Patel et al. (2012) conducted a review in Atrial Fibrillation. Left atrial appendage (LAA) exclusion vs. Oral systemic anticoagulation was evaluated. Mechanical exclusion of the left atrial appendage offers an alternative strategy for stroke prevention in patients with atrial fibrillation who are deemed unsuitable for oral anticoagulation.

synapsesocial.com/papers/6a08ac43ab15ea61dee90282https://doi.org/10.1155/2012/610827
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications1995 · 2,287 citations
  2. 2Anatomy of the Normal Left Atrial Appendage1997 · 420 citations
  3. 3The Cox-Maze Procedure for Lone Atrial Fibrillation2011 · 227 citations
  4. 4Left atrial appendage closure with Amplatzer cardiac plug for stroke prevention in atrial fibrillation: Initial Asia‐Pacific experience2011 · 163 citations
  5. 5Transcatheter occlusion of the left atrial appendage for stroke prevention2005 · 28 citations