Key result
In patients with mechanical heart valve prostheses receiving acenocoumarol, major hemorrhagic and thromboembolic complications occurred in 11.1% of patients over a mean follow-up of 43.3 months.
Population
225 patients who underwent at least one successful mechanical valve replacement in 2000 at a single center…
Design
Cohort
Follow-up
mean 43.3 +/- 9.2 months
Authors
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High complication rates with acenocoumarol suggest closer INR monitoring may help; leaves open whether alternatives reduce events in mechanical valves.
Observational (n=225)
No
Patients with mechanical heart valves receiving acenocoumarol experience significant rates of major hemorrhagic and thromboembolic complications, largely driven by poor maintenance of therapeutic INR levels.
Trzeciak et al. (2010) conducted an observational in Mechanical heart valve prostheses (n=225). Acenocoumarol was evaluated on Major hemorrhagic and thromboembolic complications. In patients with mechanical heart valve prostheses receiving acenocoumarol, major hemorrhagic and thromboembolic complications occurred in 11.1% of patients over a mean follow-up of 43.3 months.
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