June 8, 2022Open Access

Complications occurred in 25% of patients, with 95.1% of these occurring in patients with mechanical prostheses compared to 4.9% in those with biological prostheses (p=0.005).

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Why the study?

Heart valve replacement with mechanical or biological prostheses carries risks of thromboembolism and anticoagulation-related bleeding, prompting evaluation of these complications and determination of their risk probability.

Does the choice of mechanical versus biological valve prosthesis affect the risk of thromboembolic and hemorrhagic complications in patients receiving VKA therapy?

Population

163 patients undergoing valve replacement surgery with mechanical or biological prostheses

Comparison

Mechanical vs biological valve prostheses (both treated with VKA)

Design

Cohort study

Authors

FMFernando Fabián Sánchez Medina OVOlivia Valenzuela LVLucía Concepción Valenzuela-Molina

Discussion

Member takes

Overview

Complications predominate with mechanical valves and nonoptimal INR; hypothesis-generating for refined selection and monitoring strategies.

Structured PICO

Does the choice of mechanical versus biological valve prosthesis affect the risk of thromboembolic and hemorrhagic complications in patients receiving VKA therapy?

Population

163 patients who underwent valve replacement surgery from 2002 to 2016 with either mechanical or biological prostheses, excluding those with comorbidities and other risk factors for thrombosis and/or bleeding.

Intervention

Mechanical valve prosthesis with vitamin K antagonist (VKA) complementary anticoagulation therapy

Comparator

Biological valve prosthesis with vitamin K antagonist (VKA) complementary anticoagulation therapy

Outcome

Thromboembolic and hemorrhagic complicationssafety

Mechanical valve prostheses are associated with a significantly higher risk of thromboembolic and hemorrhagic complications compared to biological prostheses, largely driven by nonoptimal INR control.

Cite This Study

Medina et al. (2022) studied this question.

synapsesocial.com/papers/6a7d2c08da72e8de9c279189 https://doi.org/10.21203/rs.3.rs-1274039/v1

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June 8, 2022Open Access

Complications occurred in 25% of patients, with 95.1% of these occurring in patients with mechanical prostheses compared to 4.9% in those with biological prostheses (p=0.005).

View Full Paper

Ask AI

Bookmark

Why the study?

Does the choice of mechanical versus biological valve prosthesis affect the risk of thromboembolic and hemorrhagic complications in patients receiving VKA therapy?

Population

163 patients undergoing valve replacement surgery with mechanical or biological prostheses

Comparison

Mechanical vs biological valve prostheses (both treated with VKA)

Design

Cohort study

Authors

FMFernando Fabián Sánchez Medina OVOlivia Valenzuela LVLucía Concepción Valenzuela-Molina

Discussion

Member takes

Overview

Complications predominate with mechanical valves and nonoptimal INR; hypothesis-generating for refined selection and monitoring strategies.

Structured PICO

Does the choice of mechanical versus biological valve prosthesis affect the risk of thromboembolic and hemorrhagic complications in patients receiving VKA therapy?

Population

Intervention

Mechanical valve prosthesis with vitamin K antagonist (VKA) complementary anticoagulation therapy

Comparator

Biological valve prosthesis with vitamin K antagonist (VKA) complementary anticoagulation therapy

Outcome

Thromboembolic and hemorrhagic complicationssafety

Cite This Study

Medina et al. (2022) studied this question.

synapsesocial.com/papers/6a7d2c08da72e8de9c279189 https://doi.org/10.21203/rs.3.rs-1274039/v1

View Full Paper

Ask AI

Bookmark