Key result
Commercial rabbit tissue thromboplastins appeared sufficiently sensitive for safe anticoagulant control, although Manchester and Thrombotest reagents yielded greater discrimination.
Why the study?
How do different thromboplastin reagents compare in standardizing laboratory tests for controlling coumarin anticoagulant therapy?
Population
Specimens from a large group of patients treated with coumarin
Comparison
Five rabbit tissue thromboplastins and ox brain… vs Manchester Comparative Reagent
Design
Other
Authors
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Reassures labs on rabbit thromboplastin adequacy; leaves open whether higher-discrimination reagents improve outcomes in contemporary cohorts.
Observational
How do different thromboplastin reagents compare in standardizing laboratory tests for controlling coumarin anticoagulant therapy?
Commercial rabbit tissue thromboplastins are sufficiently sensitive for monitoring coumarin therapy, though human and ox brain reagents provide greater discrimination.
Zucker et al. (1970) conducted an observational in Patients treated with coumarin. Five rabbit tissue thromboplastins and ox brain Thrombotest reagent vs. Manchester Comparative Reagent (human brain thromboplastin) was evaluated on Discrimination in assaying the prothrombin complex. Commercial rabbit tissue thromboplastins appeared sufficiently sensitive for safe anticoagulant control, although Manchester and Thrombotest reagents yielded greater discrimination.
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