Key result
Porcine xenograft valves in the aortic position had a higher rate of degeneration requiring reoperation compared to those in the mitral position (23.8% vs 7.8%, p<0.01).
Population
211 patients who had porcine xenograft valve replacements at Henry Ford Hospital between October 1971 and…
Design
Cohort
Follow-up
60-89 months
Authors
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Aortic porcine xenografts may warrant closer surveillance; leaves open position-specific durability mechanisms in younger patients.
Cohort (n=211)
No
Absolute Event Rate: 23.8% vs 7.8%
p-value: p=< 0.01
Long-term follow-up indicates that porcine xenograft valve degeneration is more likely in the aortic position than the mitral position, and is associated with younger patient age (<25 years) and longer duration of implantation.
Lakier et al. (1980) conducted a cohort in Valvular heart disease requiring replacement (n=211). Porcine xenograft valve replacement (aortic position) vs. Porcine xenograft valve replacement (mitral position) was evaluated on Reoperation due to hemodynamically significant porcine xenograft degeneration (p=< 0.01). Porcine xenograft valves in the aortic position had a higher rate of degeneration requiring reoperation compared to those in the mitral position (23.8% vs 7.8%, p<0.01).
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