What is the clinical evidence from this study?

Study design: Observational. Population: Valvular heart disease (n=66). Intervention: Hancock porcine xenograft valve prosthesis. Primary outcome: Hospital deaths.

February 1, 1979HeartOpen Access

Early clinical experience with the Hancock porcine xenograft valve prosthesis.

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Key result

Insertion of the Hancock porcine xenograft valve prosthesis in 66 patients across a 2-year period resulted in a hospital mortality rate of 3%.

Population

66 patients, average age 55 years, requiring valve replacement for indications including rheumatic heart…

Design

Case_series

Follow-up

hospital stay

Authors

CSC T SangArizona State University JWJ WallworkPapworth Hospital NHS Foundation Trust HMHugh MillerGuy's Hospital

Discussion

Member takes

Implication

Supports early feasibility; leaves open durability, comparative efficacy, and need for prospective data.

Key Points

To evaluate the clinical outcomes associated with the Hancock porcine xenograft valve prosthesis in patients undergoing valve replacement.
Inserted 75 Hancock porcine xenograft valves in 66 patients over a 2-year period.
Performed surgeries for conditions including rheumatic heart disease, valve dysfunction, and others.
Included additional procedures like coronary artery bypass grafts and tricuspid annuloplasty.
Two hospital deaths occurred, accounting for 3% of the cases.
Valves were successfully placed in mitral (45), aortic (28), and tricuspid (2) positions.
Nine patients required double valve replacement.

Study Design

Type

Observational (n=66)

Structured PICO

Population

66 patients (33 male, 33 female), average age 55 years (range 14 to 69 years), requiring valve replacement for indications including rheumatic heart disease, prosthetic valve dysfunction, papillary muscle dysfunction, degenerative valve disease, subacute bacterial endocarditis, luetic valve disease, congenital heart disease, and traumatic valve damage.

Intervention

Insertion of Hancock porcine xenograft valve prosthesis (75 valves placed in 66 patients: 45 mitral, 28 aortic, 2 tricuspid; 9 required double valve replacement).

Outcome

Hospital deathshard clinical

Early clinical experience with the Hancock porcine xenograft valve prosthesis demonstrates feasibility with a low hospital mortality rate of 3%.

Cite This Study

Sang et al. (1979) conducted an observational in Valvular heart disease (n=66). Hancock porcine xenograft valve prosthesis was evaluated on Hospital deaths. Insertion of the Hancock porcine xenograft valve prosthesis in 66 patients across a 2-year period resulted in a hospital mortality rate of 3%.

synapsesocial.com/papers/6a08cba58bd2868868ba065d https://doi.org/10.1136/hrt.41.2.226

Topics

Valvular heart disease

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Early clinical experience with the Hancock porcine xenograft valve prosthesis.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Early clinical experience with the Hancock porcine xenograft valve prosthesis.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider