October 1, 1982Clinical Science
Radiotracer Methodology for the Simultaneous Estimation of Total, and Renal, Sympathetic Nervous System Activity in Humans
Population
4 patients with essential hypertension
Design
Other
Authors
Discussion
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Implication
Renal sympathetic quantification now feasible in humans; extends radiotracer methods but leaves therapeutic implications open pending validation.
Key Points
- To develop a radiotracer method for simultaneous estimation of total and renal sympathetic nervous system activity in humans.
- Measured noradrenaline spillover to plasma in patients with essential hypertension
- Analyzed total (2.58 ± 0.20 nmol/min) and renal (0.42 ± 0.25 nmol/min) noradrenaline levels
- Focused on organ-specific sympathetic tone relevant to blood pressure regulation.
- Renal noradrenaline spillover constituted approximately 16% of total spillover.
- Increased local sympathetic tone may not be caught by overall sympathetic activity tests.
Structured PICO
P
Population
4 patients with essential hypertension
I
Intervention
Radiotracer method based on the measurement of noradrenaline spillover to plasma
O
Outcome
Total and renal noradrenaline spillover to plasmasurrogate
A novel radiotracer method successfully estimated total and organ-specific (renal) sympathetic nervous system tone in humans, demonstrating that renal spillover accounts for about 16% of total noradrenaline spillover in patients with essential hypertension.
Cite This Study
Esler et al. (1982) studied this question.