Key result
ROMK1 (Kir1.1) channels are allosterically regulated by extracellular K+ and intracellular pH, with K+ regulation determined by the core region and pH coupling by the N terminus.
Population
Renal Kir1.1 (ROMK1) channels
Design
Preclinical
Authors
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May link renal K+ and pH homeostasis via ROMK1; extends channel biology but leaves open human translation.
Extracellular K+ and intracellular pH allosterically regulate renal ROMK1 channels, providing a novel link between K+ homeostasis and pH control.
Doi et al. (1996) studied this question. ROMK1 (Kir1.1) channels are allosterically regulated by extracellular K+ and intracellular pH, with K+ regulation determined by the core region and pH coupling by the N terminus.
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