Key result
Calcium-channel blockers significantly shortened early diastolic time intervals (e.g., IIA-O time from 234.6 to 204.6 ms; p<0.01) in patients with HCM, whereas beta-adrenergic blockers did not.
Why the study?
Do calcium-channel blockers compared to beta-adrenergic blockers improve early diastolic time intervals and A-wave ratio in patients with hypertrophic cardiomyopathy?
Population
Patients with hypertrophic cardiomyopathy (HCM)
Comparison
Calcium-channel blockers for more than three… vs Beta-adrenergic blockers for more than three…
Design
Cohort
Follow-up
more than three months
Authors
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May favor CCBs over beta-blockers for diastolic parameters in HCM; hypothesis-generating and requires randomized confirmation.
Cohort
Do calcium-channel blockers compared to beta-adrenergic blockers improve early diastolic time intervals and A-wave ratio in patients with hypertrophic cardiomyopathy?
p-value: p=<0.01
Calcium-channel blockers, but not beta-adrenergic blockers, improve early diastolic filling rate in patients with hypertrophic cardiomyopathy.
Doiuchi et al. (1987) conducted a cohort in Hypertrophic cardiomyopathy (HCM). Calcium-channel blockers vs. Beta-adrenergic blockers was evaluated on Diastolic time intervals (IIA-O, IIA-MVO, MVO-O times) and A-wave ratio (p=<0.01). Calcium-channel blockers significantly shortened early diastolic time intervals (e.g., IIA-O time from 234.6 to 204.6 ms; p<0.01) in patients with HCM, whereas beta-adrenergic blockers did not.
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