Why the study?
Does the addition of calcium channel blockers with negative chronotropic properties provide better delay of ischemia than nonchronotropic ones when added to beta-blockers in patients with exercise-induced angina?
Population
335 patients with exercise-induced angina pectoris on baseline beta-blocker treatment
Comparison
Addition of calcium channel blockers to baseline… vs Comparison between different calcium channel…
Design
RCT, double-blind
Follow-up
10 weeks
Authors
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Supports mibefradil over other CCBs for greater ischemia delay on beta-blockers; extends RCT data but dizziness risk warrants caution.
Does the addition of calcium channel blockers with negative chronotropic properties provide better delay of ischemia than nonchronotropic ones when added to beta-blockers in patients with exercise-induced angina?
Calcium channel blockers with negative chronotropic properties provide greater delay of ischemia when added to beta-blockers in exercise-induced angina, but may be limited by an increased risk of dizziness.
Cleophas et al. (1999) studied this question.
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