Key result
Atenolol and diltiazem did not significantly affect maximal exercise duration, maximal oxygen uptake, or ventilatory threshold in untrained subjects with essential hypertension.
Why the study?
Does atenolol compared to diltiazem reduce or improve cardiopulmonary response during exercise in sedentary patients with essential hypertension?
Population
16 sedentary patients with essential hypertension
Comparison
Atenolol administered for 6 weeks vs Diltiazem sustained-release 300 mg administered…
Design
RCT, randomized, cross-over, double-blind
Follow-up
6 weeks per treatment arm
Authors
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Neither atenolol nor diltiazem limits exercise tolerance in sedentary hypertensives; extends evidence on preserved cardiopulmonary responses to guide agent selection.
RCT (n=16)
Double-blind
Cross-over
Does atenolol compared to diltiazem reduce or improve cardiopulmonary response during exercise in sedentary patients with essential hypertension?
In sedentary hypertensive patients, neither atenolol nor diltiazem limits maximal exercise tolerance, though diltiazem better preserves the circulatory profile.
Cohen‐Solal et al. (1993) conducted an RCT in Essential hypertension (n=16). Atenolol vs. Diltiazem sustained-release 300 mg was evaluated on Maximal exercise duration, maximal oxygen uptake, ventilatory threshold, and ventilatory parameters during exercise. Atenolol and diltiazem did not significantly affect maximal exercise duration, maximal oxygen uptake, or ventilatory threshold in untrained subjects with essential hypertension.
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