What question did this study set out to answer?

This study aims to compare the metabolic effects of diltiazem and atenolol on carbohydrate and lipoprotein metabolism in hypertensive patients.

July 1, 1989Journal of Hypertension

Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

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Authors

TPThomas PollareSophiahemmet Hospital HLHans LithellGeneral / Preventive / Lipids CMClaes MörlinUppsala University Hospital

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Implication

Randomized trial compares metabolic impacts of diltiazem and atenolol in hypertensive individuals, highlighting important implications for diabetes risk.

Key Points

This study aims to compare the metabolic effects of diltiazem and atenolol on carbohydrate and lipoprotein metabolism in hypertensive patients.
Randomized, double-blind trial with n=58 hypertensive patients.
Compared effects of diltiazem (329 mg/day) and atenolol (67 mg/day) on metabolism.
Insulin-mediated glucose uptake measured using the euglycaemic insulin clamp technique.
Atenolol treatment reduced insulin-mediated glucose uptake from 7.1 to 5.6 mg/kg per min (P=0.05).
Plasma glucose increased during atenolol: fasting state (P<0.05) and IVGTT (P<0.01).
Diltiazem treatment decreased insulin peak by 13% (P<0.05) but showed no change in glucose uptake.

Cite This Study

Pollare et al. (1989) studied this question.

synapsesocial.com/papers/6a21f8cf00d082f62f96ea02 https://doi.org/10.1097/00004872-198907000-00006

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Implication

Randomized trial compares metabolic impacts of diltiazem and atenolol in hypertensive individuals, highlighting important implications for diabetes risk.

Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups

Discussion

Member takes

Implication

Key Points

Cite This Study

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