Why the study?
Does diltiazem sustained-release formulation compared to metoprolol improve diurnal ambulatory blood pressure and plasma lipoprotein levels in patients with primary hypertension?
Population
49 patients with primary hypertension
Comparison
Diltiazem sustained-release formulation for 16… vs Metoprolol for 16 weeks (crossover design)
Design
RCT, randomized, double-blind
Follow-up
16 weeks
Authors
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Lipid effects may offset metoprolol's BP advantage over diltiazem; challenges beta-blocker preference in uncomplicated primary hypertension.
Does diltiazem sustained-release formulation compared to metoprolol improve diurnal ambulatory blood pressure and plasma lipoprotein levels in patients with primary hypertension?
While metoprolol provides greater ambulatory blood pressure reduction than diltiazem, its deleterious effects on lipid profiles may counterbalance this benefit in patients with primary hypertension.
Lacourcière et al. (1990) studied this question.
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