Key result
Pindolol significantly increased HDL-C and reduced the total-C to HDL-C ratio compared to placebo, whereas metoprolol had no effect on HDL-C, though both drugs reduced blood pressure.
Why the study?
Do pindolol and metoprolol affect plasma lipids and lipoproteins in hypertensive patients?
Population
16 hypertensive patients (WHO I-I)
Comparison
Pindolol and metoprolol vs Placebo period
Design
Other
Follow-up
12 weeks per treatment period
Authors
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Pindolol may improve lipid profiles versus metoprolol in hypertension; hypothesis-generating and should not yet change practice.
RCT (n=16)
Do pindolol and metoprolol affect plasma lipids and lipoproteins in hypertensive patients?
In hypertensive patients, pindolol favorably alters the lipid profile by increasing HDL-C, whereas metoprolol does not, though both effectively lower blood pressure.
Pasotti et al. (1982) conducted an RCT in Hypertension (n=16). Pindolol and metoprolol vs. Placebo was evaluated on Plasma lipids and lipoproteins (total-C, TG, LDL-C, HDL-C). Pindolol significantly increased HDL-C and reduced the total-C to HDL-C ratio compared to placebo, whereas metoprolol had no effect on HDL-C, though both drugs reduced blood pressure.
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