Key result
This review discusses the clinical course and pathogenesis of hypertrophic cardiomyopathy, speculating that it and hypertension may both be caused by systemic disorders of calcium channels.
The paper provides a brief overview of hypertrophic cardiomyopathy and speculates on a shared calcium channel-related pathogenesis with hypertension.
Offers no basis to change clinical practice in hypertrophic cardiomyopathy; leaves open shared calcium channel pathogenesis with hypertension for investigation.
Hypertrophic cardiomyopathy is characterized by a hypertrophic and non‐dilated left ventricle with disproportionate involvement of the intraventricular septum compared to the free walls, and by varying degrees of outflow obstruction during systole. Its symptoms and clinical course, pathogenesis and treatment are briefly discussed. It is speculated whether hypertrophic cardiomyopathy and hypertension are both caused by systemic disorders of calcium channels and calcium uptake and binding by cardiac and smooth muscle membranes, respectively.
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Knud Landmark (1986) conducted a review in Hypertrophic cardiomyopathy. This review discusses the clinical course and pathogenesis of hypertrophic cardiomyopathy, speculating that it and hypertension may both be caused by systemic disorders of calcium channels.
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