Key result
Increasing heart rate via electrical stimulation to 50-170 beats/min did not reduce percent regurgitation, whereas isoproterenol increased forward flow and reduced percent regurgitation.
Why the study?
Does increasing heart rate via electrical stimulation or isoproterenol reduce per cent regurgitation in patients with severe aortic regurgitation?
Population
9 patients with severe aortic regurgitation evaluated at the time of operation.
Comparison
Heart rate control and increase by electrical… vs Baseline/slower heart rates, and constant heart…
Design
Case_series
Authors
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Pacing-induced tachycardia may not reduce regurgitation in severe AR; this case leaves open isoproterenol's potential benefit.
Does increasing heart rate via electrical stimulation or isoproterenol reduce per cent regurgitation in patients with severe aortic regurgitation?
In patients with severe aortic regurgitation, pacing-induced tachycardia alone does not reduce regurgitant fraction, whereas isoproterenol improves forward flow and reduces regurgitation primarily through its chronotropic effects.
Brawley et al. (1967) studied Severe aortic regurgitation (n=9). Electrical stimulation and isoproterenol was evaluated on Aortic blood flow, pressures, and per cent regurgitation. Increasing heart rate via electrical stimulation to 50-170 beats/min did not reduce percent regurgitation, whereas isoproterenol increased forward flow and reduced percent regurgitation.
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