Key result
Severe mitral regurgitation resulted in an abnormal aortic flow pattern characterized by early peak flow and abnormally high forward flow during the first half of ejection.
Why the study?
How does severe mitral regurgitation affect the pattern of instantaneous ascending aortic blood flow?
Population
5 patients with severe, pure mitral regurgitation, and 9 dogs in which mitral regurgitation was produced…
Design
Preclinical
Authors
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Warrants caution interpreting aortic flow in severe mitral regurgitation; leaves open human translation of altered ejection dynamics.
Observational (n=14)
How does severe mitral regurgitation affect the pattern of instantaneous ascending aortic blood flow?
Severe mitral regurgitation alters aortic flow dynamics by shifting forward ejection to early systole, reflecting the ventricle's inability to sustain forward flow late in systole.
Elkins et al. (1967) conducted an observational in Severe, pure mitral regurgitation (n=14). Mitral regurgitation was evaluated on Instantaneous ascending aortic blood flow pattern. Severe mitral regurgitation resulted in an abnormal aortic flow pattern characterized by early peak flow and abnormally high forward flow during the first half of ejection.
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