September 1, 1957Circulation Research163 citationsOpen Access
Hemodynamic Effects of Quantitatively Varied Experimental Aortic Regurgitation
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Structured PICO
What are the hemodynamic effects of quantitatively varied experimental aortic regurgitation in a canine model?
P
Population
Canine preparation
I
Intervention
Acutely produced, metered and controllably varied aortic regurgitant flow, with or without added mitral regurgitation
O
Outcome
Hemodynamic effects (effective cardiac output, peripheral resistance, left ventricular end-diastolic pressure, left ventricular function curve, mean left atrial pressure)surrogate
Experimental acute aortic regurgitation significantly impairs forward cardiac output and elevates left ventricular filling pressures, with hemodynamics further altered by concomitant mitral regurgitation.
Abstract
A canine preparation was devised in which aortic regurgitant flow could be acutely produced, metered and controllably varied. Aortic regurgitant flows in excess of the dog's resting cardiac output resulted in a marked decrease of effective cardiac output, a substantial rise of peripheral resistance and left ventricular end-diastolic pressure, and a marked depression of the left ventricular function curve, with little change in the mean left atrial pressure. When mitral regurgitation was added to aortic regurgitation, effective cardiac output, stroke work and left ventricular end-diastolic pressure fell, while left atrial pressure rose.
Cite This Study
Welch et al. (1957) studied this question.