What does this research mean for the field?

Left ventricular size and shape are major determinants of mitral regurgitant orifice area and resultant flow in acute mitral regurgitation, where increased load increases flow primarily by enlarging the orifice area, while increased contractility decreases flow by reducing the orifice area. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1977CirculationOpen Access

The effects of left ventricular load and contractility on mitral regurgitant orifice size and flow in the dog.

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Why the study?

Does alteration of left ventricular load and contractility affect mitral regurgitant orifice size and flow in dogs with acute mitral regurgitation?

Population

12 dogs with acute mitral regurgitation produced by closed chest partial valvulectomy

Comparison

Augmentation of left ventricular end-diastolic… vs Baseline (following MR induction)

Design

Preclinical

Authors

DBD M BorgenhagenBorgWarner (Brazil)JSJuan R. SerurUniversity of Southern California RGR GorlinBrigham and Women's Hospital

Discussion

Member takes

Implication

Acute MR orifice dynamics respond to load/contractility in dogs; leaves open translation to human therapy or guidelines.

Structured PICO

Does alteration of left ventricular load and contractility affect mitral regurgitant orifice size and flow in dogs with acute mitral regurgitation?

Population

12 dogs with acute mitral regurgitation produced by closed chest partial valvulectomy

Intervention

Augmentation of left ventricular end-diastolic volume (EDV), increased aortic resistance (angiotensin), and increased ventricular contractility (calcium or epinephrine)

Comparator

Baseline (following MR induction)

Outcome

Mitral regurgitant flow (MRF) and mitral regurgitant orifice area (MRA)surrogate

Left ventricular size and shape are major determinants of mitral regurgitant orifice area and flow in acute mitral regurgitation, explaining the effects of ventricular loading and volume on MR severity.

Cite This Study

Borgenhagen et al. (1977) studied this question.

synapsesocial.com/papers/6a11d074dcb035f2f8fd3b9d https://doi.org/10.1161/01.cir.56.1.106

Topics

Mitral valve intervention

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The effects of left ventricular load and contractility on mitral regurgitant orifice size and flow in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The effects of left ventricular load and contractility on mitral regurgitant orifice size and flow in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider