Key result
Diastolic mechanical stimulation eliminates ectopic beats in computational models, while systolic stimulation triggers arrhythmia.
Why the study?
Dysfunction of cardiac electrical mechanisms causes significant mortality, and mechano-electric feedback plays a key role in mechanical generation and recovery from arrhythmia.
Does mechanical stimulation affect the cardiac cycle and arrhythmia generation or recovery in a computational model of the heart?
Population
A minimal, multiscale model of the heart coupling organ-level and contractile dynamics
Comparison
Mechanical stimulation impulse timing, amplitude, and duration
Design
Computational modeling study
Authors
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Hypothesis-generating for timing-specific mechanical effects on arrhythmia; requires in vivo validation before clinical consideration.
Does mechanical stimulation affect the cardiac cycle and arrhythmia generation or recovery in a computational model of the heart?
A computational model demonstrates that mechanical stimulation can either stabilize arrhythmias or generate them depending on its timing within the cardiac cycle.
Pearce et al. (2021) studied Arrhythmia. Mechanical stimulation (computational model) was evaluated on Cardiac cycle response (pulse rate stabilization and arrhythmia generation). Mechanical stimulation introduced during the diastolic period in a computational heart model stabilized pulse rate and eliminated ectopic beats, whereas systolic stimulation generated arrhythmia.
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