What does this research mean for the field?

Mechanoelectric feedback mechanisms, particularly shortening velocity, significantly influence cardiac mechanical response, and modulating stretch-activated channels could potentially restore cardiac output in left bundle branch block. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 24, 2023Computers in Biology and MedicineOpen Access

Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology

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Why the study?

How mechanoelectric feedback mechanisms interact and affect cardiac output remains incompletely understood.

Population

Electromechanical computer model of a dog heart with biventricular geometry of 500K tetrahedral elements

Comparison

Different mechanoelectric feedback mechanisms in healthy function vs left bundle branch block pathology

Design

Computer simulation study

Authors

APArgyrios PetrasAustrian Academy of Sciences MGMatthias A. F. GsellMedical University of Graz CAChristoph M. AugustinMedical University of Graz

Discussion

Member takes

Implication

Hypothesis-generating for SAC modulation in LBBB models; leaves open in vivo validation before any clinical consideration.

Structured PICO

Population

Electromechanical computer model of a dog heart (biventricular geometry of 500K tetrahedral elements)

Intervention

Simulation of mechanoelectric feedback mechanisms (stretch activated channels, active tension model dependent on stretch and shortening velocity) and left bundle branch block pathology

Outcome

Cardiac output, pressure-volume loops, activation times, stretch, and tensionsurrogate

Computational modeling suggests mechanoelectric feedback mechanisms, particularly shortening velocity and stretch-activated channels, play significant roles in cardiac mechanics and could potentially mitigate activation problems in left bundle branch block.

Cite This Study

Petras et al. (2023) studied this question.

synapsesocial.com/papers/6a1d1f68102421609404e34f https://doi.org/10.1016/j.compbiomed.2023.106696

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Ask AI

Bookmark

Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider