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June 15, 2001Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences

Mechanoelectric feedback in cardiac cells

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Population

Cardiac cells

Design

Review

Authors

PKPeter KöhlFSFrederick Sachs

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Overview

Mechanistic summary of cardiac MEF supports basic research; leaves open translation to arrhythmia prediction or therapy.

Structured PICO

P
Population
Cardiac cells
I
Intervention
Mechanoelectric feedback (MEF)

This review summarizes the mechanisms of mechanoelectric feedback in cardiac cells, including stretch activation of ion channels and mechanical modulation of calcium handling.

Cite This Study

Köhl et al. (2001) studied this question.

synapsesocial.com/papers/6a7271bd35aa2c282ce34157https://doi.org/10.1098/rsta.2001.0824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.1982 · 560 citations
  2. 2Generation and propagation of ectopic beats induced by spatially localized Na–K pump inhibition in atrial network models1993 · 73 citations
  3. 3Mechanical stretch activates the stress‐activated protein kinase in cardiac myocytes1996 · 242 citations
  4. 4A possible mechanism for large stretch-induced increase in [Ca2+]i in isolated guinea-pig ventricular myocytes1996 · 69 citations
  5. 5Stretch‐activated anion currents of rabbit cardiac myocytes.1992 · 210 citations