Key result
Combined subaortic septal myectomy and anterior leaflet retention plasty decreased the mean LVOT pressure gradient from 84 to 19 mm Hg (p < 0.001) in HOCM patients with significant SAM.
Why the study?
Does combined subaortic septal myectomy and ALRP improve LVOT obstruction and clinical outcomes in adult HOCM patients with significant SAM?
Population
25 adult patients with hypertrophic obstructive cardiomyopathy and significant systolic anterior motion of…
Design
Cohort
Follow-up
median 2.5 years (range 0.8 to 14 years)
Authors
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May support combined myectomy and retention plasty for SAM in HOCM; leaves open need for randomized confirmation.
Observational (n=25)
Does combined subaortic septal myectomy and ALRP improve LVOT obstruction and clinical outcomes in adult HOCM patients with significant SAM?
Absolute Event Rate: 19% vs 84%
p-value: p=<0.001
Combined subaortic septal myectomy and anterior leaflet retention plasty effectively reduces LVOT gradients and improves symptoms in HOCM patients with significant systolic anterior motion.
Nasseri et al. (2011) conducted an observational in Hypertrophic obstructive cardiomyopathy (HOCM) with significant systolic anterior motion (SAM) (n=25). Combined subaortic septal myectomy and anterior leaflet retention plasty (ALRP) was evaluated on Mean LVOT pressure gradient (p=<0.001). Combined subaortic septal myectomy and anterior leaflet retention plasty decreased the mean LVOT pressure gradient from 84 to 19 mm Hg (p < 0.001) in HOCM patients with significant SAM.
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