Why the study?
Does HIF-1alpha mediate the upregulation of myocardial endothelin-1 expression in the failing heart?
Population
Rat cardiomyocytes, rats with myocardial infarction, and hamsters with cardiomyopathy
Comparison
Mitochondrial inhibitor and antisense… vs Control/untreated cells and animals
Design
Preclinical
Authors
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HIF-1α may link to ET-1 upregulation in stressed cardiomyocytes; leaves open its role and therapeutic targeting in human heart failure.
Does HIF-1alpha mediate the upregulation of myocardial endothelin-1 expression in the failing heart?
The study identifies a novel molecular mechanism where HIF-1alpha, induced to stimulate glycolysis in heart failure, maladaptively elevates cardiac ET-1 gene expression.
Kakinuma et al. (2001) studied this question.
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