Key result
Ischemic heart failure in rats led to a 10.6-fold upregulation of left ventricular ET-1 mRNA at 1 week (P=0.002), which correlated significantly with left ventricular end-diastolic pressure.
Population
Rats with ischemic heart failure due to left coronary artery ligation
Comparison
Left coronary artery ligation vs Non-infarcted tissue
Design
Preclinical
Follow-up
up to 6 weeks
Authors
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ET-1 rises early and tracks LVEDP in rat ischemic HF; leaves open causal role and therapeutic targeting in patients.
Effect estimate: 10.6-fold upregulation
p-value: p=0.002
In a rat model of ischemic heart failure, cardiac ET-1 mRNA expression is significantly upregulated and correlates with disease severity (LVEDP).
Tønnessen et al. (1997) studied Ischemic heart failure. Left coronary artery ligation vs. Non-infarcted tissue was evaluated on Left ventricular ET-1 mRNA levels at 1 week (10.6-fold upregulation, p=0.002). Ischemic heart failure in rats led to a 10.6-fold upregulation of left ventricular ET-1 mRNA at 1 week (P=0.002), which correlated significantly with left ventricular end-diastolic pressure.
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