Population
Rats with congestive heart failure induced by left coronary artery occlusion, with left ventricular…
Comparison
Induction of congestive heart failure via left… vs Sham-operated control animals
Design
Preclinical
Follow-up
1 week (for inclusion assessment)
Authors
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Supports endothelin pathway investigation in experimental CHF; leaves open clinical translation and therapeutic targeting.
Cardiopulmonary endothelin synthesis is significantly upregulated in rats with heart failure following myocardial infarction, supporting a pathophysiological role for endothelin in congestive heart failure.
Theis Tønnessen (1998) studied this question.
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