Key result
FBG ≥ 7.0 mmol/l is linked to ~79% higher incident hypertension risk vs < 5.6 mmol/l.
Why the study?
Relationships between blood glucose levels, insulin action, and the incidence of hypertension have not been well established epidemiologically.
Does high fasting blood glucose predict the incidence of hypertension in middle-aged adults without baseline hypertension?
Cohort (n=2,210)
Does high fasting blood glucose predict the incidence of hypertension in middle-aged adults without baseline hypertension?
Effect estimate: HR 1.79
Fasting blood glucose is an independent predictor of incident hypertension in middle-aged adults, even among those with normal HbA1c and insulin sensitivity.
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May flag middle-aged adults for closer BP surveillance; leaves open causal role and prevention trials.
Tatsumi et al. (2019) conducted a cohort in Hypertension incidence (n=2,210). Fasting blood glucose ≥ 7.0 mmol/l vs. Fasting blood glucose < 5.6 mmol/l was evaluated on Incidence of hypertension (blood pressure ≥ 140/90 mm Hg or receiving antihypertensive treatment) (HR 1.79). Fasting blood glucose ≥ 7.0 mmol/l was independently associated with an increased risk of incident hypertension compared to FBG < 5.6 mmol/l (HR 1.79) in middle-aged Japanese adults.
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