Key result
Generalized seizures trigger basal Takotsubo syndrome with LVEF recovery to 50%.
Why the study?
Basal type Takotsubo syndrome in the context of epileptiform seizures is relatively rare but represents an important diagnosis to recognise.
Case Report (n=1)
No
This case highlights the importance of cardiac assessment in patients presenting with generalised tonic-clonic seizures to identify potential atypical Takotsubo syndrome.
May support cardiac evaluation after seizures; extends basal Takotsubo spectrum but remains hypothesis-generating.
Takotsubo syndrome (TTS) is a reversible form of left ventricular dysfunction commonly associated with physical or emotional stress. It is characterised by chest pain and elevated troponin levels, thereby mimicking acute coronary syndrome however there is typically no evidence of obstructive coronary artery disease on invasive angiography. TTS is characterised by apical ballooning or akinesis with basal hyperkinesia. Basal type Takotsubo Syndrome (bTTS) is a less common atypical variant identified by basal akinesis and apical hyperkinesis. Although both forms have been shown to be associated with neurological disease and intracranial haemorrhage or ischaemic stroke, bTTS in the context of epileptiform seizures is relatively rare but an important diagnosis to recognise. We describe a case of a 73-year-old woman who presented to hospital with generalised tonic clonic seizures, followed by centralised chest pain, troponin elevation due to bTTS. This case describes an uncommon presentation of bTTS and highlights the importance of cardiac assessment in patients presenting with generalised tonic-clonic seizures.
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O’Neill et al. (2022) conducted a case report in Basal type Takotsubo Syndrome (bTTS) (n=1). Supportive heart failure therapy (Bisoprolol and Ramipril) was evaluated on Improvement in global left ventricular function. A 73-year-old woman presenting with generalized tonic-clonic seizures was diagnosed with basal type Takotsubo Syndrome, which improved to a left ventricular ejection fraction of 50% at 40 days.
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