Key result
Takotsubo syndrome linked to ~105% higher mortality than the background population, exceeding STEMI risk.
Why the study?
Data regarding the long-term risk of heart failure in patients with takotsubo syndrome are sparse.
Does takotsubo syndrome increase the long-term risk of death and heart failure hospitalization compared to the background population and STEMI survivors?
Population
881 patients with first-time TTS alive at discharge in Denmark
Comparison
TTS survivors vs matched background population (1:4) and matched STEMI survivors (1:3)
Design
Nationwide observational cohort study
Follow-up
Mean 2.9 years
Authors
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Takotsubo survivors may need closer long-term surveillance; leaves open whether interventions can mitigate excess mortality versus STEMI.
Cohort (n=881)
Yes
Does takotsubo syndrome increase the long-term risk of death and heart failure hospitalization compared to the background population and STEMI survivors?
Effect estimate: HR 2.05 (95% CI 1.62-2.60)
Survivors of takotsubo syndrome face significantly higher long-term mortality than both the general population and STEMI survivors, along with an elevated risk of heart failure hospitalization compared to the general population.
Butt et al. (2022) conducted a cohort in Takotsubo syndrome (n=881). Takotsubo syndrome vs. Background population and STEMI survivors was evaluated on death (HR 2.05, 95% CI 1.62-2.60). Survivors of takotsubo syndrome had higher mortality than the background population (HR 2.05; 95% CI 1.62-2.60) and STEMI survivors (HR 1.69; 95% CI 1.34-2.13).
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