Key result
Acute flaccid paralysis or pulmonary edema in EV71 linked to ~15-fold higher motor dysfunction risk.
Observational (n=61)
Yes
Effect estimate: OR 15 (95% CI 3-79)
p-value: p=<.001
Enterovirus 71 causes serious neurological disease in young children, with long-term functional morbidity primarily associated with paresis linked to gray matter involvement in the brainstem or spinal cord.
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High-risk EV71 presentations warrant targeted motor surveillance; leaves open prospective studies to modify long-term outcomes.
Teoh et al. (2016) conducted an observational in Enterovirus 71 neurological disease (n=61). Children with EV71 neurological disease presenting with acute flaccid paralysis or pulmonary edema had significantly greater frequencies of motor dysfunction at follow-up (OR 15; 95% CI 3-79; P<.001).
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