Key result
A single oral dose of minoxidil significantly increased cardiac index from 2.34 to 2.95 l/min/m2 (p<0.02) and reduced systemic vascular resistance in patients with chronic left ventricular failure.
Why the study?
Does a single oral dose of minoxidil improve acute hemodynamics in patients with chronic left ventricular failure?
Population
18 patients with chronic left ventricular failure caused by ischemic or primary cardiomyopathy.
Comparison
Single oral dose of minoxidil. vs Baseline (pre-treatment).
Design
Cohort
Follow-up
8 hours
Authors
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Acute hemodynamic effects of minoxidil in chronic LV failure are hypothesis-generating; randomized trials needed before clinical adoption.
Observational (n=18)
Does a single oral dose of minoxidil improve acute hemodynamics in patients with chronic left ventricular failure?
A single oral dose of minoxidil acutely improves cardiac index and reduces systemic vascular resistance in patients with chronic left ventricular failure.
Franciosa et al. (1981) conducted an observational in chronic left ventricular failure (n=18). minoxidil was evaluated on acute hemodynamic effects (cardiac index and systemic vascular resistance). A single oral dose of minoxidil significantly increased cardiac index from 2.34 to 2.95 l/min/m2 (p<0.02) and reduced systemic vascular resistance in patients with chronic left ventricular failure.
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