Key result
Mathematical recalibration of commercial cTnI assays reduces between-assay variation by ~45% at low concentrations.
Why the study?
Does mathematical recalibration improve measurement equivalence among different commercial cardiac troponin I assays in samples from patients with suspected acute myocardial infarction?
Population
90 patients with suspected acute myocardial infarction providing cTnI-positive samples, plus 7 serum pools…
Comparison
Measurement using 16 commercial cardiac troponin… vs Median cTnI concentrations measured by the 16…
Design
Other
Authors
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May aid troponin assay standardization; pilot data leave clinical outcome validation open.
Cross-Sectional (n=90)
Does mathematical recalibration improve measurement equivalence among different commercial cardiac troponin I assays in samples from patients with suspected acute myocardial infarction?
Absolute Event Rate: 22% vs 40%
Mathematical recalibration significantly improves measurement equivalence among commercial cardiac troponin I assays, indicating that standardization is feasible and effective at reducing inter-assay bias.
Tate et al. (2015) conducted a cross-sectional in suspected acute myocardial infarction (n=90). Mathematical recalibration vs. Uncalibrated assays was evaluated on Between-assay variation at low cTnI concentration. Mathematical recalibration of 16 commercial cardiac troponin I assays reduced between-assay variation from 40% to 22% at low concentrations, demonstrating improved measurement equivalence.
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