Atherosclerosis Inflammation Imaging with ¹⁸F-FDG PET: Carotid, Iliac, and Femoral Uptake Reproducibility, Quantification Methods, and Recommendations
Key result
18F-FDG PET imaging of carotid, iliac, and femoral arteries demonstrated excellent short-term reproducibility for both mean and maximum target-to-background ratios (ICC > 0.8 for all measures).
Why the study?
Is 18F-FDG PET imaging reproducible for quantifying atherosclerosis inflammation in carotid, iliac, and femoral arteries?
Population
20 patients with vascular disease
Design
Cohort
Follow-up
14 days
Authors
Discussion
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Member takes
Implication
May facilitate serial vascular inflammation assessment in research; leaves open impact on clinical outcomes or management.
Study Design
Type
Observational (n=20)
Structured PICO
Is 18F-FDG PET imaging reproducible for quantifying atherosclerosis inflammation in carotid, iliac, and femoral arteries?
P
Population
20 patients with vascular disease
I
Intervention
18F-FDG PET/CT imaging of the iliac, femoral, and carotid arteries 90 min after administration, repeated at 14 days
O
Outcome
Reproducibility of 18F-FDG uptake measurement (interscan, interobserver, and intraobserver agreement) using mean and maximum target-to-background ratio (TBR)surrogate
Main Result
Effect estimate: ICC > 0.8
18F-FDG PET imaging demonstrates highly reproducible mean and maximum TBR measurements in carotid, iliac, and femoral arteries, supporting its use for tracking atherosclerosis inflammation.
Cite This Study
Rudd et al. (2008) conducted an observational in Vascular disease (n=20). 18F-FDG PET imaging was evaluated on Short-term reproducibility of 18F-FDG signal (interscan, interobserver, and intraobserver agreement) (ICC > 0.8). 18F-FDG PET imaging of carotid, iliac, and femoral arteries demonstrated excellent short-term reproducibility for both mean and maximum target-to-background ratios (ICC > 0.8 for all measures).