Key result
Women with HFpEF exhibit distinct pathophysiology and worse symptoms that may require sex-specific care.
Why the study?
HFpEF shows female predominance and has exceeded HFrEF as the primary form of heart failure in women, who present with smaller cardiac chambers, higher LVEF, and more severe symptoms and signs without established consensus.
Highlights the distinct clinical presentation of HFpEF in women, who exhibit smaller cardiac chambers and higher LVEF but more severe symptoms.
May support sex-specific HFpEF strategies in women; leaves open prospective trials before practice change.
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Espíndola et al. (2024) conducted a review in Heart Failure with Preserved Ejection Fraction (HFpEF). Women with heart failure with preserved ejection fraction exhibit distinct pathophysiological mechanisms, more severe symptoms, and may require sex-specific diagnostic and therapeutic approaches.
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