Key result
Proteomic changes in myofilament proteins are essential to adaptive physiological regulation of cardiac output but become maladaptive in cardiac disorders.
Design
Review
Authors
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Should not yet change practice; leaves open proteomic validation in prospective trials.
This review highlights the role of proteomic changes in cardiac myofilament proteins in both physiological adaptation and maladaptive cardiac disorders, and discusses techniques to study them.
Yuan et al. (2008) conducted a review in Cardiac disorders. Proteomic changes in myofilament proteins are essential to adaptive physiological regulation of cardiac output but become maladaptive in cardiac disorders.
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