Key result
Altered post-translational modifications of cardiac myofilament proteins, including thick and thin filaments and titin, play a key role in the pathophysiology of heart failure and ischemia.
Understanding the functional consequences of altered post-translational modifications of cardiac myofilament proteins is essential for developing targeted therapies for heart failure and ischemia.
May inform PTM-targeted therapies in heart failure; leaves open prospective validation before clinical adoption.
This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.
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Jin et al. (2008) conducted a review in Heart failure and ischemia. Altered post-translational modifications of cardiac myofilament proteins, including thick and thin filaments and titin, play a key role in the pathophysiology of heart failure and ischemia.
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